Salarin c synthesis
WebOct 24, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … WebApr 20, 2024 · The eastern section of the macrocyclic marine natural product salarin C from the sponge Fascaplysinopsis sp. was synthesized employing a halogen dance reaction to …
Salarin c synthesis
Did you know?
WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The … WebJul 7, 2008 · A novel nitrogenous macrolide, designated salarin C (3), was isolated from the Madagascan sponge Fascaplysinopsis sp. The structure of the compound was elucidated by interpretation of MS and 1D and 2D NMR spectra.Salarin C is closely related to salarin A and is considered to be the precursor of salarins A and B (1,2).Air oxidation was found to …
WebNov 11, 2013 · Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl … WebDideoxysalarin C 133, a potential intermediate for the synthesis of the marine natural macrolide salarin C (08TL4355), was synthesized through a convergent strategy by Altmann and Schrof. This structurally intriguing compound contains a trisubstituted oxazole ring embedded in an 18-membered macrolactone cycle.
WebThe synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being replaced by alkene moieties. In the key step, ring-closing metathesis exclusively afforded the (E)-product. WebSynthesis and Stability Studies of a Simplified, Thiazole-Containing Macrocycle of the Anticancer Agent Salarin C . Continue Bridging the gap between natural product synthesis and drug discovery. Continue Pyrrole-2-Aminoimidazole Marine Alkaloids. Continue Total Synthesis of (-)-Salinosporamide A.
WebNov 26, 2024 · Abstract. A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is …
WebNov 1, 2013 · Derivatives of salarin A, salarin C and tulearin A were prepared and bio-evaluated as inhibitors of K562 leukemia cells and interesting preliminary SAR (structure activity relationship) information was obtained from the products. Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were … samsung a13 screen mirroringWebNov 11, 2013 · 1. Introduction. Four groups of nitrogenous macrolides (Figure 1) were isolated from the Madagascar Fascaplysinopsis sp. sponge collected in Salary Bay, ca. 100 km north of Tulear [1,2,3].Among these metabolites the most abundant and active compound was salarin C (1), a potent inhibitor of proliferation of K562 leukemia cells (in … samsung a13 sim freeWebOct 24, 2024 · Macrocyclic Core of Salarin C: Synthesis and Oxidation. Jan-Niklas Schäckermann TU Braunschweig , Institute of Organic Chemistry , Hagenring 30 , 38106 Braunschweig , Germany. samsung a13 sim free mobile phoneWebNov 2, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … samsung a13 sim free dealsWebMay 5, 2024 · The synthesis was inspired by Kashman's hypothesis on the biomimetic oxidation of salarin C to salarin A. Clean conversion to the triacylamine partial structure of salarin A occurred on treatment with photochemically generated singlet oxygen. Thus, a Wasserman-type oxidative rearrangement is chemically possible in this case. samsung a13 shock proof caseWebDOI: 10.1016/J.TETLET.2008.05.038 Corpus ID: 96996339; Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide @article{Bishara2008SalarinCA, title={Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide}, author={Ashgan Bishara and Amira Rudi and Maurice Aknin and Drorit Neumann and Nathalie Ben-Califa and Yoel Kashman}, … samsung a13 screen coverWebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. samsung a13 shockproof case