Efna5 and epha5 in brain
WebMar 1, 2012 · This suggests that EphA4 may have a role in the maintenance of neuronal connections, synaptic formation, and plasticity in the human brain, as suggested for EphA5 . The present data, together with expression data in animal models, indicate that EphA4 expression is highly conserved among mammalian species; this may reflect its … WebMay function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. 2 publications
Efna5 and epha5 in brain
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WebEnables ephrin receptor binding activity. Involved in brain development. Predicted to be located in adherens junction and basement membrane. Predicted to be active in GABA-ergic synapse and plasma membrane. Predicted to be anchored component of external side of plasma membrane. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of … WebFunctions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis ( By similarity ). By similarity.
WebMay 16, 2016 · By sequencing proteins from BT20 human breast carcinoma and HeLa cells that interacted with the receptor tyrosine kinase REK7 (EPHA5; 600004), followed by … WebThe interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for …
WebTogether with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the … WebThe interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell …
WebJul 12, 2024 · To determine cell type specific expression of efnA5 and potential single-cell changes related to ALS, we performed RNAscope in situ hybridizations in lumbar spinal …
WebNational Center for Biotechnology Information ram priceWebNov 25, 2016 · The survival analysis showed that patients with negative or weak expression of EphA5 protein had a poor outcome than those with positive expression (P = 0.004). Conclusions: Our results show that EphA5 may be a potential biomarker for distinguishing high-and low-grade ovarian serous carcinoma and a potential prognostic marker. dr jindal glaucoma gbmcWebWe analyzed EphA4 expression and activation in postmortem brain tissue from 19 patients who died after acute closed head injury and had evidence of diffuse axonal injury and 8 controls. We also examined downstream pathways that are mediated by EphA4 in human astrocyte cell cultures. Our results indicate that, after TBI in humans, EphA4 ... dr jinali dioraWebMar 21, 2024 · Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, … dr jindal glaucomaWebJun 16, 2024 · Four of ten hits belonged to the EPH receptor family: EPHA4, EPHA5, EPHA6, and EPHB1. ... EFNA5 treatment resulted in decreased RAC1 activity in SK-Mel-28 but increased RAC1 activity in SK-Mel-103 (Figures S5 A and S5B). Additionally, SK-Mel-103-vector or SK-Mel-103-GMPR cells were infected with control or EPHA4 shRNAs … dr jindalWebAug 31, 2007 · By RT-PCR and confocal microscopy analysis, Konstantinova et al. (2007) demonstrated that mouse and human pancreatic beta cells expressed ephrin-A5 … dr. ji neurologyWebSep 22, 2009 · Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous … dr jindal neurologist